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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species.
Yang, Wu; Wang, Yufeng; Lai, Amy; Clark, Charles G; Corte, James R; Fang, Tianan; Gilligan, Paul J; Jeon, Yoon; Pabbisetty, Kumar B; Rampulla, Richard A; Mathur, Arvind; Kaspady, Mahammed; Neithnadka, Premsai Rai; Arumugam, Arunachalam; Raju, Sivashankaran; Rossi, Karen A; Myers, Joseph E; Sheriff, Steven; Lou, Zhen; Zheng, Joanna J; Chacko, Silvi A; Bozarth, Jeffrey M; Wu, Yiming; Crain, Earl J; Wong, Pancras C; Seiffert, Dietmar A; Luettgen, Joseph M; Lam, Patrick Y S; Wexler, Ruth R; Ewing, William R.
Afiliação
  • Yang W; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Wang Y; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Lai A; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Clark CG; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Corte JR; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Fang T; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Gilligan PJ; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Jeon Y; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Pabbisetty KB; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Rampulla RA; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Mathur A; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Kaspady M; Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Biocon Park, Plot nos. 2 and 3, Bommasandra-Jigani Road, Bangalore 560100, India.
  • Neithnadka PR; Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Biocon Park, Plot nos. 2 and 3, Bommasandra-Jigani Road, Bangalore 560100, India.
  • Arumugam A; Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Biocon Park, Plot nos. 2 and 3, Bommasandra-Jigani Road, Bangalore 560100, India.
  • Raju S; Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd., Biocon Park, Plot nos. 2 and 3, Bommasandra-Jigani Road, Bangalore 560100, India.
  • Rossi KA; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Myers JE; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Sheriff S; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Lou Z; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Zheng JJ; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Chacko SA; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Bozarth JM; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Wu Y; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Crain EJ; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Wong PC; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Seiffert DA; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Luettgen JM; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Lam PYS; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Wexler RR; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
  • Ewing WR; Research and Development, Bristol Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08540, United States.
J Med Chem ; 63(13): 7226-7242, 2020 07 09.
Article em En | MEDLINE | ID: mdl-32456431
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Fibrinolíticos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator XIa / Fibrinolíticos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos