Diverse Secondary Metabolites from a Lichen-Derived Amycolatopsis Strain.
Curr Microbiol
; 77(9): 2104-2110, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32468182
ABSTRACT
In this study, the secondary metabolites of a lichen-derived actinomycete strain Amycolatopsis sp. YIM 130687 were investigated intensively by using three different media (4#, 302#, and 312#) for fermentation. A total of 21 compounds were isolated from the fermented extraction of the strain. The structures of all compounds were identified by the examination of HRESIMS and NMR spectra. Compounds 1-3, 5, 6, 21 were only found in the cultivation on 302# medium, while compounds 4, 9-11 were only obtained when the strain was cultured on 312# medium. On the other hand, compounds 7, 8, and 20 were only isolated from the fermentation product on 4# medium. The antimicrobial activity test showed that compound 9 had significant inhibitory effects on bacterial pathogens of Staphylococcus aureus and MRSA with the MICs of 2 µg/ml and fungal pathogens of Botrytis cinerea and Fusarium graminearum with the MICs of 1 µg/ml.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Líquens
Idioma:
En
Revista:
Curr Microbiol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China