Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-&#954;B pathway.

Li, Yaping; Huang, Baohua; Yang, Hua; Kan, Shuang; Yao, Yanling; Liu, Xin; Pu, Shiming; He, Guozhang; Khan, Taj-Malook; Qi, Guangying; Zhou, Zuping; Shu, Wei; Chen, Ming

Latexin deficiency in mice up-regulates inflammation and aggravates colitis through HECTD1/Rps3/NF-κB pathway.

Li, Yaping; Huang, Baohua; Yang, Hua; Kan, Shuang; Yao, Yanling; Liu, Xin; Pu, Shiming; He, Guozhang; Khan, Taj-Malook; Qi, Guangying; Zhou, Zuping; Shu, Wei; Chen, Ming.

Afiliação

Li Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Huang B; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Yang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Kan S; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Yao Y; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Liu X; Central Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, P.R. China.
Pu S; School of Life Sciences, Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, 541004, P.R. China.
He G; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Khan TM; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China.
Qi G; School of Basic Medical Science, Guilin Medical University, Guilin, 541004, P.R. China.
Zhou Z; School of Life Sciences, Research Center for Biomedical Sciences, Guangxi Normal University, Guilin, 541004, P.R. China.
Shu W; College of Biotechnology, Guilin Medical University, Guilin, 541004, P.R. China. shuwei7866@126.com.
Chen M; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, 541004, P.R. China. chenmingprotein@163.com.

Sci Rep ; 10(1): 9868, 2020 06 17.

Article em En | MEDLINE | ID: mdl-32555320

Assuntos

Colite/genética; Colite/patologia; Técnicas de Inativação de Genes; Proteínas do Tecido Nervoso/deficiência; Proteínas do Tecido Nervoso/genética; Transdução de Sinais/genética; Regulação para Cima; Sequência de Aminoácidos; Animais; Linhagem Celular; Humanos; Inflamação/genética; Inflamação/patologia; Camundongos; Inibidor de NF-kappaB alfa/metabolismo; NF-kappa B/metabolismo; Proteínas Ribossômicas/metabolismo; Fator de Necrose Tumoral alfa/metabolismo; Ubiquitina-Proteína Ligases/química; Ubiquitina-Proteína Ligases/metabolismo; Ubiquitinação

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Regulação para Cima / Colite / Técnicas de Inativação de Genes / Proteínas do Tecido Nervoso Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article

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