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Does SARS-CoV-2 Trigger Stress-InducedAutoimmunity by Molecular Mimicry? A Hypothesis.
Cappello, Francesco; Gammazza, Antonella Marino; Dieli, Francesco; Macario, Alberto Jl.
Afiliação
  • Cappello F; Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
  • Gammazza AM; Euro-Mediterranean Institute of Science and Technology (IEMEST), 90141 Palermo, Italy.
  • Dieli F; Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
  • de Macario; Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo,90127 Palermo, Italy.
  • Macario AJ; Euro-Mediterranean Institute of Science and Technology (IEMEST), 90141 Palermo, Italy.
J Clin Med ; 9(7)2020 Jun 29.
Article em En | MEDLINE | ID: mdl-32610587
ABSTRACT
Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host's antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália