Rapid spread of OXA-244-producing <i>Escherichia coli</i> ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020.

Kremer, Katrin; Kramer, Rolf; Neumann, Bernd; Haller, Sebastian; Pfennigwerth, Niels; Werner, Guido; Gatermann, Sören; Schroten, Horst; Eckmanns, Tim; Hans, Jörg B

Rapid spread of OXA-244-producing Escherichia coli ST38 in Germany: insights from an integrated molecular surveillance approach; 2017 to January 2020.

Kremer, Katrin; Kramer, Rolf; Neumann, Bernd; Haller, Sebastian; Pfennigwerth, Niels; Werner, Guido; Gatermann, Sören; Schroten, Horst; Eckmanns, Tim; Hans, Jörg B.

Afiliação

Kremer K; Robert Koch-Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
Kramer R; Postgraduate Training for Applied Epidemiology (PAE), Robert Koch-Institute, Berlin, Germany.
Neumann B; These authors contributed equally to this manuscript.
Haller S; Robert Koch-Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
Pfennigwerth N; These authors contributed equally to this manuscript.
Werner G; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
Gatermann S; Robert Koch-Institute, Department for Infectious Disease Epidemiology, Berlin, Germany.
Schroten H; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.
Eckmanns T; Robert Koch Institute, Division of Nosocomial Pathogens and Antibiotic Resistance, Wernigerode, Germany.
Hans JB; National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany.

Euro Surveill ; 25(25)2020 06.

Article em En | MEDLINE | ID: mdl-32613940

ABSTRACT

ABSTRACT

Annually, increasing numbers of OXA-244-producing Escherichia coli in 13 German federal states prompted us to initiate an outbreak investigation. Whole genome sequencing revealed that among 148 isolates analysed, most belonged to sequence type 38 with 62 isolates forming a genetically distinct cluster. Although no epidemiological link could be identified between cases, ongoing investigations suggest non-healthcare associated transmission. A screening-PCR was developed facilitating early detection of ST38 cluster isolates to identify the source and transmission route.

Assuntos

Infecções Comunitárias Adquiridas/epidemiologia; Infecções por Escherichia coli/diagnóstico; Infecções por Escherichia coli/epidemiologia; Escherichia coli/isolamento & purificação; Sequenciamento Completo do Genoma/métodos; Adolescente; Adulto; Idoso; Antibacterianos/farmacologia; Criança; Pré-Escolar; Escherichia coli/efeitos dos fármacos; Escherichia coli/genética; Infecções por Escherichia coli/tratamento farmacológico; Proteínas de Escherichia coli/genética; Alemanha/epidemiologia; Humanos; Lactente; Masculino; Pessoa de Meia-Idade; Reação em Cadeia da Polimerase; beta-Lactamases/genética

Palavras-chave

Carbapenemase; Enterobacterales; WGS; whole genome sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Comunitárias Adquiridas / Escherichia coli / Infecções por Escherichia coli / Sequenciamento Completo do Genoma Tipo de estudo: Prognostic_studies / Screening_studies Limite: Adolescent / Adult / Aged / Child / Child, preschool / Humans / Infant / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Euro Surveill Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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