Fungal Melanin Rewires Macrophage Metabolism.

Papon, Nicolas; Gangneux, Jean-Pierre; Delneste, Yves

Papon, Nicolas; Gangneux, Jean-Pierre; Delneste, Yves.

Afiliação

Papon N; Host-Pathogen Interaction Study Group (GEIHP) EA3142, Université d'Angers and Université de Brest, Angers, France; Interactions Cellulaires et Applications Thérapeutiques (ICAT), Structure Féderative de Recherche (SFR) 4208, Université d'Angers, Angers, France. Electronic address: nicolas.papon@univ-angers.fr.
Gangneux JP; Université Rennes, Centre Hospitalier Universitaire (CHU) Rennes, Institut National de la Santé et de la Recherche Médicale (INSERM), Ecole des Hautes Études en Santé Publique (EHESP), Institut de Recherche en Santé, Environnement, et Travail (IRSET) Unité Mixte de Recherche (UMR) S1085, Rennes, France.
Delneste Y; Interactions Cellulaires et Applications Thérapeutiques (ICAT), Structure Féderative de Recherche (SFR) 4208, Université d'Angers, Angers, France; Centre de Recherche en Cancérologie et Immunologie Nantes Angers (CRCINA), INSERM, Université de Nantes and Université d'Angers, Angers, France; CHU Angers, Département d'Immunologie Allergologie, Angers, France. Electronic address: yves.delneste@univ-angers.fr.

Trends Biochem Sci ; 45(9): 728-730, 2020 09.

Article em En | MEDLINE | ID: mdl-32622750

ABSTRACT

ABSTRACT

Aspergillus fumigatus is a deadly fungal pathogen in immunocompromised patients. A report by Gonçalves et al. reveals that melanin, a secondary metabolite present at the surface of infecting fungal spores, induces glycolysis in macrophages to promote inflammatory responses. This opens a window for the development of innovative host-directed antifungal therapies.

Assuntos

Antifúngicos; Melaninas; Aspergillus fumigatus; Humanos; Macrófagos; Esporos Fúngicos

Palavras-chave

Aspergillus; fungal infections; glycolysis; macrophages; melanin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Melaninas / Antifúngicos Limite: Humans Idioma: En Revista: Trends Biochem Sci Ano de publicação: 2020 Tipo de documento: Article

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