Antifungal Agent 4-AN Changes the Genome-Wide Expression Profile, Downregulates Virulence-Associated Genes and Induces Necrosis in <i>Candida albicans</i> Cells.

Martyna, Aleksandra; Maslyk, Maciej; Janeczko, Monika; Kochanowicz, Elzbieta; Gielniewski, Bartlomiej; Swiercz, Aleksandra; Demchuk, Oleg M; Kubinski, Konrad

Antifungal Agent 4-AN Changes the Genome-Wide Expression Profile, Downregulates Virulence-Associated Genes and Induces Necrosis in Candida albicans Cells.

Martyna, Aleksandra; Maslyk, Maciej; Janeczko, Monika; Kochanowicz, Elzbieta; Gielniewski, Bartlomiej; Swiercz, Aleksandra; Demchuk, Oleg M; Kubinski, Konrad.

Afiliação

Martyna A; Department of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Maslyk M; Department of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Janeczko M; Department of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Kochanowicz E; Department of Molecular Biology, Institute of Biological Sciences, The John Paul II Catholic University of Lublin, ul. Konstantynów 1i, 20-708 Lublin, Poland.
Gielniewski B; Laboratory of Molecular Neurobiology, Neurobiology Center, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093 Warsaw, Poland.
Swiercz A; Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan, Poland.
Demchuk OM; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznan, Poland.
Kubinski K; Pharmaceutical Research Institute, Rydygiera Street 8, 01-793 Warsaw, Poland.

Molecules ; 25(12)2020 Jun 25.

Article em En | MEDLINE | ID: mdl-32630522

Assuntos

Antifúngicos/farmacologia; Candida albicans/crescimento & desenvolvimento; Proteínas Fúngicas/metabolismo; Regulação Fúngica da Expressão Gênica/efeitos dos fármacos; Genoma Fúngico; Necrose; Virulência/genética; Biofilmes/efeitos dos fármacos; Biofilmes/crescimento & desenvolvimento; Candida albicans/efeitos dos fármacos; Candida albicans/genética; Proteínas Fúngicas/genética; Perfilação da Expressão Gênica

Palavras-chave

4-AN; C. albicans; antifungals; gene expression; necrosis; synergy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Virulência / Candida albicans / Proteínas Fúngicas / Regulação Fúngica da Expressão Gênica / Genoma Fúngico / Antifúngicos / Necrose Tipo de estudo: Risk_factors_studies Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

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