[BONE METABOLISM AND BONE MINERAL DENSITY IN CHILDREN WITH RECURRENT BRONCHITIS].

ABSTRACT

The aim - to determine the bone metabolism status and bone mineral density (BMD) in children with recurrent bronchitis (RB). 120 children aged 6 to 10 years were examined. Formed 2 groups 1st group - children with RB (n=60); 2nd group - children occasionally suffering of upper respiratory tract infections (n=60). The average age was 8 years 2 months. Among children with RB, compared with children of the 2nd group, an increase in the number of patients with an increase in alkaline phosphatase activity (by 35.0%) (p<0.05), and serum osteocalcin level (by 66.7%) (p<0.05) was revealed, collagen type 1 degradation products (by 15.0%) (p<0.05), parathyroid hormone (by 13.3%) (p<0.05), decrease of serum 25(OH)D less than 30 ng/ml (by 59.3%) (p<0.05). A DXA in children with RB showed the presence of 24 (40.0%) episodes of decreased BMD in the L1, 25 (41.7%) episodes in L2, 24 (40.0%) episodes in L3, 27 (45.0%) episodes in L4, 28 (46.7%) cases in the left femur neck, 22 (36.7%) cases in the right femur neck. In children with RB was established activation of bone resorption on background of vitamin D deficiency and BMD decrease.