The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses.

Campillo-Davo, Diana; Flumens, Donovan; Lion, Eva

Campillo-Davo, Diana; Flumens, Donovan; Lion, Eva.

Afiliação

Campillo-Davo D; Tumor Immunology Group, Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.
Flumens D; Tumor Immunology Group, Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.
Lion E; Tumor Immunology Group, Laboratory of Experimental Hematology, Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.

Cells ; 9(7)2020 07 18.

Article em En | MEDLINE | ID: mdl-32708366

Assuntos

Afinidade de Anticorpos/imunologia; Neoplasias/imunologia; Engenharia de Proteínas; Receptores de Antígenos de Linfócitos T/metabolismo; Linfócitos T/imunologia; Animais; Epitopos/imunologia; Humanos

Palavras-chave

T-cell fitness; T-cell receptor; TCR affinity; TCR avidity; TCR engineering; affinity-enhanced; cancer immunotherapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos T / Linfócitos T / Engenharia de Proteínas / Afinidade de Anticorpos / Neoplasias Limite: Animals / Humans Idioma: En Revista: Cells Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bélgica

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