Two-site immunoenzymometric assays for serum IgG subclass infant/maternal ratios at full-term.
J Immunol Methods
; 106(1): 71-81, 1988 Jan 21.
Article
em En
| MEDLINE
| ID: mdl-3276788
ABSTRACT
Improvements were made in the range, precision, convenience, automation, and reliability of our previously published two-site immunoenzymometric assays using mouse monoclonal antibodies specific for human IgG and its subclasses. The serum concentration ratios for these immunoglobulin isotypes were measured in neonatal/maternal paired sera from 119 normal full-term deliveries. These ratios are significantly different than 1.0 (P = 0.001) for total IgG, IgG1, and IgG2 (show non-equality of paired neonatal/maternal sera concentrations) but are not significantly different than 1.0 for IgG3 and IgG4. On average, IgG1 is elevated 61%, and IgG2 is depressed 11% in the full-term neonate with respect to its own mother. In some pregnancies, active transport of IgG1 may be selectively enhanced by low material IgG1 concentration and selectively inhibited by high levels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
/
Recém-Nascido
/
Técnicas Imunoenzimáticas
/
Sangue Fetal
/
Alótipos de Imunoglobulina
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
J Immunol Methods
Ano de publicação:
1988
Tipo de documento:
Article