Histological Patterns of Epithelial Alterations in Keratoconus.
J Ophthalmol
; 2020: 1468258, 2020.
Article
em En
| MEDLINE
| ID: mdl-32802486
ABSTRACT
PURPOSE:
The purpose of this study was to confirm the presence of specific patterns of epithelial response in corneal buttons from keratoconus patients.METHODS:
This was a retrospective and descriptive study. 90 penetrating keratoplasty specimens obtained from patients diagnosed with keratoconus were evaluated using bright-field microscopy. Morphologically identifiable characteristics including epithelial cell density and epithelial thickness were analyzed on hematoxylin and eosin- (H&E-) and periodic acid of Schiff- (PAS-) stained slides.RESULTS:
Three distinctive patterns of epithelial alteration of the central cornea were established. Pattern 3, in which the central epithelium was as thick as peripheral epithelium, was the commonest (44.4%), followed by the pattern 2, defined as central epithelium thinner than periphery epithelium (38.9%), and the uncommonest pattern was number 1, with central epithelium thicker than the periphery (16.7%).CONCLUSIONS:
Three distinctive histologic patterns that could potentially have a diagnostic and prognostic value in keratoconus patients were found.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Ophthalmol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha