Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals.
Trends Biotechnol
; 38(9): 1034-1044, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32818443
ABSTRACT
Production of biologics in plants, or plant molecular pharming, is a promising protein expression technology that is receiving increasing attention from the pharmaceutical industry. Previously, low expression yields of recombinant proteins and the realization that certain post-translational modifications (PTMs) may not occur optimally limited the widespread acceptance of the technology. However, molecular engineering of the plant secretory pathway is now enabling the production of increasingly complex biomolecules using tailored protein-specific approaches to ensure their maturation. These involve the elimination of undesired processing events, and the introduction of heterologous biosynthetic machinery to support the production of specific target proteins. Here, we discuss recent advances in the production of pharmaceutical proteins in plants, which leverage the unique advantages of the technology.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Plantas
/
Plantas
/
Proteínas Recombinantes
/
Via Secretória
Limite:
Humans
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
2020
Tipo de documento:
Article