Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum.
Planta Med
; 86(16): 1216-1224, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32819010
ABSTRACT
Three new depsidones, parmosidones Fâ-âG (1â-â2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines Aâ-âC (4â-â6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their α-glucosidase inhibitory activities. Newly reported benzylated depsidones 1 and 2 in particular inhibited α-glucosidase with IC50 values of 2.2 and 4.3 µM, respectively, and are thus more potent than the positive control, acarbose.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfa-Glucosidases
/
Líquens
Idioma:
En
Revista:
Planta Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Tailândia