Your browser doesn't support javascript.
loading
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
Yamaguchi, Toshihiro; Sumida, Tomokazu S; Nomura, Seitaro; Satoh, Masahiro; Higo, Tomoaki; Ito, Masamichi; Ko, Toshiyuki; Fujita, Kanna; Sweet, Mary E; Sanbe, Atsushi; Yoshimi, Kenji; Manabe, Ichiro; Sasaoka, Toshikuni; Taylor, Matthew R G; Toko, Haruhiro; Takimoto, Eiki; Naito, Atsuhiko T; Komuro, Issei.
Afiliação
  • Yamaguchi T; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sumida TS; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Nomura S; Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.
  • Satoh M; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Higo T; Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo, Tokyo, Japan.
  • Ito M; Genome Science Division, Research Center for Advanced Science and Technologies, The University of Tokyo, Tokyo, Japan.
  • Ko T; Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
  • Fujita K; Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Sweet ME; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Sanbe A; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yoshimi K; Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Manabe I; Human Medical Genetics and Genomics, University of Colorado, Boulder, CO, USA.
  • Sasaoka T; Department of Pharmacotherapeutics, School of Pharmacy, Iwate Medical University, Morioka, Japan.
  • Taylor MRG; Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Toko H; Department of Disease Biology and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Takimoto E; Department of Comparative and Experimental Medicine, Brain Research Institute, Niigata University, Niigata, Japan.
  • Naito AT; Human Medical Genetics and Genomics, University of Colorado, Boulder, CO, USA.
  • Komuro I; Cardiovascular Institute and Adult Medical Genetics Program, University of Colorado, Boulder, CO, USA.
Nat Commun ; 11(1): 4364, 2020 08 31.
Article em En | MEDLINE | ID: mdl-32868781
ABSTRACT
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhythmia. Comprehensive single-cell resolution analysis identifies the presence of D1R-expressing CMs in both heart failure model mice and in heart failure patients with sustained ventricular tachycardia. Overexpression of D1R in CMs disturbs normal calcium handling while CM-specific deletion of D1R ameliorates heart failure-associated ventricular arrhythmia. Thus, cardiac D1R has the potential to become a therapeutic target for preventing heart failure-associated ventricular arrhythmia.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Receptores de Dopamina D1 / Miócitos Cardíacos / Insuficiência Cardíaca Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Receptores de Dopamina D1 / Miócitos Cardíacos / Insuficiência Cardíaca Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão