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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out.
Loupe, Jacob M; Pinto, Ricardo Mouro; Kim, Kyung-Hee; Gillis, Tammy; Mysore, Jayalakshmi S; Andrew, Marissa A; Kovalenko, Marina; Murtha, Ryan; Seong, IhnSik; Gusella, James F; Kwak, Seung; Howland, David; Lee, Ramee; Lee, Jong-Min; Wheeler, Vanessa C; MacDonald, Marcy E.
Afiliação
  • Loupe JM; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Pinto RM; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
  • Kim KH; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gillis T; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
  • Mysore JS; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Andrew MA; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
  • Kovalenko M; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Murtha R; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Seong I; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gusella JF; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Kwak S; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Howland D; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Lee R; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
  • Lee JM; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Wheeler VC; Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.
  • MacDonald ME; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Hum Mol Genet ; 29(18): 3044-3053, 2020 11 04.
Article em En | MEDLINE | ID: mdl-32876667
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleotídeo Redutases / Doença de Huntington / Proteínas de Ciclo Celular / Endodesoxirribonucleases / Exodesoxirribonucleases / Enzimas Multifuncionais / Proteína 1 Homóloga a MutL / Proteína Huntingtina Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleotídeo Redutases / Doença de Huntington / Proteínas de Ciclo Celular / Endodesoxirribonucleases / Exodesoxirribonucleases / Enzimas Multifuncionais / Proteína 1 Homóloga a MutL / Proteína Huntingtina Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos