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The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
Hur, Ji-Yeun; Frost, Georgia R; Wu, Xianzhong; Crump, Christina; Pan, Si Jia; Wong, Eitan; Barros, Marilia; Li, Thomas; Nie, Pengju; Zhai, Yujia; Wang, Jen Chyong; Tcw, Julia; Guo, Lei; McKenzie, Andrew; Ming, Chen; Zhou, Xianxiao; Wang, Minghui; Sagi, Yotam; Renton, Alan E; Esposito, Bianca T; Kim, Yong; Sadleir, Katherine R; Trinh, Ivy; Rissman, Robert A; Vassar, Robert; Zhang, Bin; Johnson, Douglas S; Masliah, Eliezer; Greengard, Paul; Goate, Alison; Li, Yue-Ming.
Afiliação
  • Hur JY; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Frost GR; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wu X; Program of Neurosciences, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
  • Crump C; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Pan SJ; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wong E; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
  • Barros M; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Li T; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Nie P; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Zhai Y; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Wang JC; Program of Neurosciences, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
  • Tcw J; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Guo L; Program of Pharmacology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY, USA.
  • McKenzie A; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Ming C; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Zhou X; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Wang M; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sagi Y; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Renton AE; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Esposito BT; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Kim Y; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Sadleir KR; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
  • Trinh I; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Rissman RA; Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Vassar R; Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
  • Zhang B; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Johnson DS; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
  • Masliah E; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
  • Greengard P; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Goate A; Department of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Li YM; Pfizer Worldwide Research and Development, Cambridge, MA, USA.
Nature ; 586(7831): 735-740, 2020 10.
Article em En | MEDLINE | ID: mdl-32879487
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Imunidade Inata / Proteínas de Membrana Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a RNA / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Imunidade Inata / Proteínas de Membrana Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Aged80 / Animals / Female / Humans / Male Idioma: En Revista: Nature Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos