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SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.
Wang, Pengfei; Liu, Lihong; Nair, Manoj S; Yin, Michael T; Luo, Yang; Wang, Qian; Yuan, Ting; Mori, Kanako; Solis, Axel Guzman; Yamashita, Masahiro; Garg, Ankur; Purpura, Lawrence J; Laracy, Justin C; Yu, Jian; Joshua-Tor, Leemor; Sodroski, Joseph; Huang, Yaoxing; Ho, David D.
Afiliação
  • Wang P; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Liu L; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Nair MS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Yin MT; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Luo Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Wang Q; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.
  • Yuan T; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Mori K; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Solis AG; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Yamashita M; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Garg A; W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Purpura LJ; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Laracy JC; Division of Infectious Diseases, Department of Internal Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Joshua-Tor L; W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Sodroski J; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Department of Microbiology, Harvard Medical School, Boston, MA, USA.
  • Huang Y; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
  • Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Emerg Microbes Infect ; 9(1): 2091-2093, 2020 Dec.
Article em En | MEDLINE | ID: mdl-32930052
ABSTRACT
We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleocapsídeo / Anticorpos Neutralizantes / Glicoproteína da Espícula de Coronavírus / Betacoronavirus / Anticorpos Antivirais Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleocapsídeo / Anticorpos Neutralizantes / Glicoproteína da Espícula de Coronavírus / Betacoronavirus / Anticorpos Antivirais Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos