Genes influenced by MEF2C contribute to neurodevelopmental disease via gene expression changes that affect multiple types of cortical excitatory neurons.

Cosgrove, Donna; Whitton, Laura; Fahey, Laura; Ó Broin, Pilib; Donohoe, Gary; Morris, Derek W

Cosgrove, Donna; Whitton, Laura; Fahey, Laura; Ó Broin, Pilib; Donohoe, Gary; Morris, Derek W.

Afiliação

Cosgrove D; Cognitive Genetics and Cognitive Therapy Group, Centre for Neuroimaging, Cognition and Genomics, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway H91CF50, Ireland.
Whitton L; Cognitive Genetics and Cognitive Therapy Group, Centre for Neuroimaging, Cognition and Genomics, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway H91CF50, Ireland.
Fahey L; Cognitive Genetics and Cognitive Therapy Group, Centre for Neuroimaging, Cognition and Genomics, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway H91CF50, Ireland.
Ó Broin P; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway H91CF50, Ireland.
Donohoe G; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway H91CF50, Ireland.
Morris DW; Cognitive Genetics and Cognitive Therapy Group, Centre for Neuroimaging, Cognition and Genomics, School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, Galway H91CF50, Ireland.

Hum Mol Genet ; 30(11): 961-970, 2021 05 31.

Article em En | MEDLINE | ID: mdl-32975584

Assuntos

Encéfalo/metabolismo; Deficiência Intelectual/genética; Transtornos do Neurodesenvolvimento/genética; Animais; Transtorno do Espectro Autista/genética; Transtorno do Espectro Autista/patologia; Regulação da Expressão Gênica/genética; Estudo de Associação Genômica Ampla; Humanos; Deficiência Intelectual/fisiopatologia; Fatores de Transcrição MEF2/genética; Camundongos; Transtornos do Neurodesenvolvimento/patologia; Neurônios/metabolismo; Neurônios/patologia; Esquizofrenia/genética; Esquizofrenia/patologia; Análise de Célula Única

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Transtornos do Neurodesenvolvimento / Deficiência Intelectual Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Irlanda

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