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Adult neurogenesis alters response to an aversive distractor in a labyrinth maze without affecting spatial learning or memory.
Schoenfeld, Timothy J; Smith, Jesse A; Sonti, Anup N; Cameron, Heather A.
Afiliação
  • Schoenfeld TJ; Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
  • Smith JA; Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
  • Sonti AN; Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
  • Cameron HA; Section on Neuroplasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.
Hippocampus ; 31(1): 102-114, 2021 01.
Article em En | MEDLINE | ID: mdl-33038042
ABSTRACT
Adult neurogenesis has been implicated in learning and memory of complex spatial environments. However, new neurons also play a role in nonmnemonic behavior, including the stress response and attention shifting. Many commonly used spatial tasks are very simple, and unsuitable for detecting neurogenesis effects, or are aversively motivated, making it difficult to dissociate effects on spatial learning and memory from effects on stress. We have therefore created a novel complex spatial environment, the flex maze, to enable reward-mediated testing of spatial learning in a flexibly configurable labyrinth. Using a pharmacogenetic method to completely inhibit neurogenesis in adulthood, we found that rats lacking new neurons (TK rats) and wild type controls completed and remembered most mazes equally well. However, control rats were slower to complete peppermint-scented mazes than other mazes, while neurogenesis-deficient rats showed no effect of mint on maze behavior, completing these mazes significantly faster than control rats. Additional testing found that wild type and TK rats showed similar detection of, avoidance of, and glucocorticoid response to the mint odor. These results suggest that spatial learning and memory in a labyrinth task is unaffected by the loss of new neurons, but that these cells affect the ability of an aversive stimulus to distract rats from completing the maze.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aprendizagem Espacial Limite: Animals Idioma: En Revista: Hippocampus Assunto da revista: CEREBRO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aprendizagem Espacial Limite: Animals Idioma: En Revista: Hippocampus Assunto da revista: CEREBRO Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos