Identification of a novel KMT2A/GIMAP8 gene fusion in a pediatric patient with acute undifferentiated leukemia.

Berg, Holly E; Blackburn, Patrick R; Baughn, Linda B; Ketterling, Rhett P; Xu, Xinjie; Greipp, Patricia T; Hoppman, Nicole L; Smadbeck, James B; Vasmatzis, George; Shi, Min; Reichard, Kaaren K; Viswanatha, David S; Jevremovic, Dragan; Maher, George M; Peterson, Jess F

Berg, Holly E; Blackburn, Patrick R; Baughn, Linda B; Ketterling, Rhett P; Xu, Xinjie; Greipp, Patricia T; Hoppman, Nicole L; Smadbeck, James B; Vasmatzis, George; Shi, Min; Reichard, Kaaren K; Viswanatha, David S; Jevremovic, Dragan; Maher, George M; Peterson, Jess F.

Afiliação

Berg HE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Blackburn PR; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Baughn LB; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Ketterling RP; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Xu X; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Greipp PT; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Hoppman NL; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Smadbeck JB; Division of Laboratory Genetics and Genomics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Vasmatzis G; Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Rochester, Minnesota, USA.
Shi M; Center for Individualized Medicine-Biomarker Discovery, Mayo Clinic, Rochester, Minnesota, USA.
Reichard KK; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Viswanatha DS; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Jevremovic D; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Maher GM; Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Peterson JF; Divison of Pediatric Hematology/Oncology, Sanford Children's Hospital, Sioux Falls, South Dakota, USA.

Genes Chromosomes Cancer ; 60(2): 108-111, 2021 02.

Article em En | MEDLINE | ID: mdl-33078871

ABSTRACT

ABSTRACT

Acute undifferentiated leukemia (AUL) is a very rare hematologic neoplasm that expresses no markers specific for either myeloid or lymphoid lineages. While commonly observed in several acute leukemias, KMT2A rearrangements in AUL have been rarely reported in the literature. We report the third case to our knowledge of AUL harboring a KMT2A rearrangement. Furthermore, the KMT2A/GIMAP8 gene fusion identified in this case represents a novel KMT2A rearrangement.

Assuntos

GTP Fosfo-Hidrolases/genética; Histona-Lisina N-Metiltransferase/genética; Leucemia Aguda Bifenotípica/genética; Proteína de Leucina Linfoide-Mieloide/genética; Proteínas de Fusão Oncogênica/genética; Criança; Humanos; Leucemia Aguda Bifenotípica/patologia; Masculino

Palavras-chave

GIMAP8; KMT2A; acute undifferentiated leukemia; mate-pair sequencing; next-generation sequencing

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Aguda Bifenotípica / Proteínas de Fusão Oncogênica / Histona-Lisina N-Metiltransferase / Proteína de Leucina Linfoide-Mieloide / GTP Fosfo-Hidrolases Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Child / Humans / Male Idioma: En Revista: Genes Chromosomes Cancer Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google