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Overcoming blood-brain barrier transport: Advances in nanoparticle-based drug delivery strategies.
Ding, Shichao; Khan, Aminul Islam; Cai, Xiaoli; Song, Yang; Lyu, Zhaoyuan; Du, Dan; Dutta, Prashanta; Lin, Yuehe.
Afiliação
  • Ding S; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Khan AI; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Cai X; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Song Y; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Lyu Z; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Du D; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Dutta P; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
  • Lin Y; School of Mechanical and Materials Engineering, Washington State University, PO Box 642920 Pullman, Washington 99164, United States.
Mater Today (Kidlington) ; 37: 112-125, 2020.
Article em En | MEDLINE | ID: mdl-33093794
ABSTRACT
The Blood-Brain Barrier (BBB), a unique structure in the central nervous system (CNS), protects the brain from bloodborne pathogens by its excellent barrier properties. Nevertheless, this barrier limits therapeutic efficacy and becomes one of the biggest challenges in new drug development for neurodegenerative disease and brain cancer. Recent breakthroughs in nanotechnology have resulted in various nanoparticles (NPs) as drug carriers to cross the BBB by different methods. This review presents the current understanding of advanced NP-mediated non-invasive drug delivery for the treatment of neurological disorders. Herein, the complex compositions and special characteristics of BBB are elucidated exhaustively. Moreover, versatile drug nanocarriers with their recent applications and their pathways on different drug delivery strategies to overcome the formidable BBB obstacle are briefly discussed. In terms of significance, this paper provides a general understanding of how various properties of nanoparticles aid in drug delivery through BBB and usher the development of novel nanotechnology-based nanomaterials for cerebral disease therapies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mater Today (Kidlington) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Mater Today (Kidlington) Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos