OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma.

Thomas, Lincy; Smith, Nataliya; Saunders, Debra; Zalles, Michelle; Gulej, Rafal; Lerner, Megan; Fung, Kar-Ming; Carcaboso, Angel M; Towner, Rheal A

Thomas, Lincy; Smith, Nataliya; Saunders, Debra; Zalles, Michelle; Gulej, Rafal; Lerner, Megan; Fung, Kar-Ming; Carcaboso, Angel M; Towner, Rheal A.

Afiliação

Thomas L; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
Smith N; The Jimmy Everest Center for Cancer and Blood Disorders in Children, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Saunders D; University of Texas Southwestern in the Division of Hematology and Oncology, Dallas, TX, USA.
Zalles M; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
Gulej R; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
Lerner M; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
Fung KM; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Carcaboso AM; Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA.
Towner RA; Pharmaceutical Department, Medical University of Lodz, Lodz, Poland.

J Transl Med ; 18(1): 424, 2020 11 10.

Article em En | MEDLINE | ID: mdl-33168005

Assuntos

Neoplasias do Tronco Encefálico; Glioma Pontino Intrínseco Difuso; Glioma; Animais; Neoplasias do Tronco Encefálico/tratamento farmacológico; Criança; Glioma/tratamento farmacológico; Humanos; Camundongos; Óxidos de Nitrogênio; Oklahoma

Palavras-chave

ACVR1 mutation; Apoptosis; Diffuse intrinsic pontine glioma (DIPG); Diffusion-weighted imaging (DWI); H3K27 trimethylation; Magnetic resonance imaging (MRI); Microvessel density (MVD); OKN-007; Patient-derived xenograft (PDX)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Tronco Encefálico / Glioma Pontino Intrínseco Difuso / Glioma Limite: Animals / Child / Humans País/Região como assunto: America do norte Idioma: En Revista: J Transl Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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