SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-<i>c</i>]pyrazoles as Potent Tubulin Polymerization Inhibitors.

Cui, Ying-Jie; Liu, Chao; Ma, Chen-Chen; Ji, Ya-Ting; Yao, Yi-Li; Tang, Long-Qian; Zhang, Cheng-Mei; Wu, Jing-De; Liu, Zhao-Peng

SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors.

Cui, Ying-Jie; Liu, Chao; Ma, Chen-Chen; Ji, Ya-Ting; Yao, Yi-Li; Tang, Long-Qian; Zhang, Cheng-Mei; Wu, Jing-De; Liu, Zhao-Peng.

Afiliação

Cui YJ; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Liu C; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Ma CC; Central Laboratory, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250012, P. R. China.
Ji YT; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Yao YL; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Tang LQ; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Zhang CM; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Wu JD; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.
Liu ZP; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, P. R. China.

J Med Chem ; 63(23): 14840-14866, 2020 12 10.

Article em En | MEDLINE | ID: mdl-33201714

Assuntos

Antineoplásicos/uso terapêutico; Indenos/uso terapêutico; Neoplasias/tratamento farmacológico; Pirazóis/uso terapêutico; Moduladores de Tubulina/uso terapêutico; Animais; Antineoplásicos/síntese química; Apoptose/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Feminino; Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos; Células Hep G2; Humanos; Indenos/síntese química; Camundongos Endogâmicos BALB C; Estrutura Molecular; Pirazóis/síntese química; Solubilidade; Relação Estrutura-Atividade; Moduladores de Tubulina/síntese química; Água/química; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Moduladores de Tubulina / Indenos / Neoplasias / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2020 Tipo de documento: Article

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