AKT/mTOR Signal Cascade and Expression of PD-1, PD-L1, and PD-L2 in Gastric Cancer.
Bull Exp Biol Med
; 170(1): 75-78, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33231797
ABSTRACT
The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Proteínas Proto-Oncogênicas c-akt
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Serina-Treonina Quinases TOR
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Antígeno B7-H1
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Proteína 2 Ligante de Morte Celular Programada 1
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Receptor de Morte Celular Programada 1
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Federação Russa