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Polypeptide-Based Molecular Platform and Its Docetaxel/Sulfo-Cy5-Containing Conjugate for Targeted Delivery to Prostate Specific Membrane Antigen.
Petrov, Stanislav A; Machulkin, Aleksei E; Uspenskaya, Anastasia A; Zyk, Nikolay Y; Nimenko, Ekaterina A; Garanina, Anastasia S; Petrov, Rostislav A; Polshakov, Vladimir I; Grishin, Yuri K; Roznyatovsky, Vitaly A; Zyk, Nikolay V; Majouga, Alexander G; Beloglazkina, Elena K.
Afiliação
  • Petrov SA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Machulkin AE; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Uspenskaya AA; Laboratory of Biomedical Nanomaterials, National University of Science and Technology MISiS, Leninskiy pr., 4, 119049 Moscow, Russia.
  • Zyk NY; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Nimenko EA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Garanina AS; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Petrov RA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Polshakov VI; Laboratory of Biomedical Nanomaterials, National University of Science and Technology MISiS, Leninskiy pr., 4, 119049 Moscow, Russia.
  • Grishin YK; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Roznyatovsky VA; Faculty of Fundamental Medicine, Lomonosov Moscow State University, Lomonosovsky Ave., 27-1, 119991 Moscow, Russia.
  • Zyk NV; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Majouga AG; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
  • Beloglazkina EK; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, 119991 Moscow, Russia.
Molecules ; 25(24)2020 Dec 08.
Article em En | MEDLINE | ID: mdl-33302417
ABSTRACT
A strategy for stereoselective synthesis of molecular platform for targeted delivery of bimodal therapeutic or theranostic agents to the prostate-specific membrane antigen (PSMA) receptor was developed. The proposed platform contains a urea-based, PSMA-targeting Glu-Urea-Lys (EuK) fragment as a vector moiety and tripeptide linker with terminal amide and azide groups for subsequent addition of two different therapeutic and diagnostic agents. The optimal method for this molecular platform synthesis includes (a) solid-phase assembly of the polypeptide linker, (b) coupling of this linker with the vector fragment, (c) attachment of 3-aminopropylazide, and (d) amide and carboxylic groups deprotection. A bimodal theranostic conjugate of the proposed platform with a cytostatic drug (docetaxel) and a fluorescent label (Sulfo-Cy5) was synthesized to demonstrate its possible sequential conjugation with different functional molecules.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Carbocianinas / Portadores de Fármacos / Glutamato Carboxipeptidase II / Docetaxel / Antígenos de Superfície Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Federação Russa
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Carbocianinas / Portadores de Fármacos / Glutamato Carboxipeptidase II / Docetaxel / Antígenos de Superfície Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Federação Russa