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Structural basis of γ-secretase inhibition and modulation by small molecule drugs.
Yang, Guanghui; Zhou, Rui; Guo, Xuefei; Yan, Chuangye; Lei, Jianlin; Shi, Yigong.
Afiliação
  • Yang G; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory for Agrobiotechnology, College of Biological Sciences, Chi
  • Zhou R; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Guo X; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Yan C; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Lei J; Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Shi Y; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Scien
Cell ; 184(2): 521-533.e14, 2021 01 21.
Article em En | MEDLINE | ID: mdl-33373587
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Inibidores Enzimáticos / Secretases da Proteína Precursora do Amiloide / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Inibidores Enzimáticos / Secretases da Proteína Precursora do Amiloide / Bibliotecas de Moléculas Pequenas Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2021 Tipo de documento: Article