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Biomimetic keratin gold nanoparticle-mediated in vitro photothermal therapy on glioblastoma multiforme.
Guglielmelli, Alexa; Rosa, Paolo; Contardi, Marco; Prato, Mirko; Mangino, Giorgio; Miglietta, Selenia; Petrozza, Vincenzo; Pani, Roberto; Calogero, Antonella; Athanassiou, Athanassia; Perotto, Giovanni; De Sio, Luciano.
Afiliação
  • Guglielmelli A; Department of Physics, University of Calabria, Arcavacata di Rende, Cosenza 87036, Italy.
  • Rosa P; CNR-Lab. LiCryl, Institute NANOTEC, Arcavacata di Rende 87036, Italy.
  • Contardi M; Department of Medico-surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Corso della Repubblica, Latina 79, 04100, Italy.
  • Prato M; Smart Materials, Istituto Italiano di Tecnologia, Via Morego, Genoa 30, 16163, Italy.
  • Mangino G; Materials Characterization Facility, Istituto Italiano di Tecnologia, Via Morego, Genova 30, 16163, Italy.
  • Miglietta S; Department of Medico-surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Corso della Repubblica, Latina 79, 04100, Italy.
  • Petrozza V; Department of Anatomy, Histology, Forensic Medicine & Orthopaedics, Sapienza University of Rome, Via Alfonso Borelli, Rome 50, 00161, Italy.
  • Pani R; Department of Medico-surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Corso della Repubblica, Latina 79, 04100, Italy.
  • Calogero A; Department of Medico-surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Corso della Repubblica, Latina 79, 04100, Italy.
  • Athanassiou A; Department of Medico-surgical Sciences & Biotechnologies, Center for Biophotonics, Sapienza University of Rome, Corso della Repubblica, Latina 79, 04100, Italy.
  • Perotto G; Smart Materials, Istituto Italiano di Tecnologia, Via Morego, Genoa 30, 16163, Italy.
  • De Sio L; Smart Materials, Istituto Italiano di Tecnologia, Via Morego, Genoa 30, 16163, Italy.
Nanomedicine (Lond) ; 16(2): 121-138, 2021 01.
Article em En | MEDLINE | ID: mdl-33426900
ABSTRACT

Aim:

To realize and characterize a new generation of keratin-coated gold nanoparticles (Ker-AuNPs) as highly efficient photosensitive nanosized therapeutics for plasmonic photothermal (PPT) therapy. Materials &

methods:

The chemical, physical, morphological and photothermal properties of Ker-AuNPs are investigated using dynamic light scattering, ζ-potential, UV-Visible, Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy, transmission electron microscopy and high-resolution thermography. In vitro experiments are performed on a human glioblastoma cell line (i.e., U87-MG), using viability assays, transmission electron microscopy, fluorescence microscopy, cytometric analyses and PPT experiments.

Results:

Experiments confirm the excellent biocompatibility of Ker-AuNPs, their efficient cellular uptake and localized photothermal heating capabilities.

Conclusion:

The reported structural and functional properties pointed out these Ker-AuNPs as a promising new tool in the field of biocompatible photothermal agents for PPT treatments against cancer-related diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Nanopartículas Metálicas Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glioblastoma / Nanopartículas Metálicas Limite: Humans Idioma: En Revista: Nanomedicine (Lond) Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália