An unconventional role of an ASB family protein in NF-&#954;B activation and inflammatory response during microbial infection and colitis.

Hou, Panpan; Jia, Penghui; Yang, Kongxiang; Li, Zibo; Tian, Tian; Lin, Yuxin; Zeng, Weijie; Xing, Fan; Chen, Yu; Li, Chunmei; Liu, Yingfang; Guo, Deyin

An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis.

Hou, Panpan; Jia, Penghui; Yang, Kongxiang; Li, Zibo; Tian, Tian; Lin, Yuxin; Zeng, Weijie; Xing, Fan; Chen, Yu; Li, Chunmei; Liu, Yingfang; Guo, Deyin.

Afiliação

Hou P; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Jia P; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Yang K; Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Li Z; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Tian T; The Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.
Lin Y; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Zeng W; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Xing F; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Chen Y; Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan 430072, China.
Li C; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Liu Y; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Guo D; MOE Key Laboratory of Tropical Disease Control, Centre for Infection and Immunity Study, Seventh Affiliated Hospital, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China; guodeyin@mail.sysu.edu.cn.

Proc Natl Acad Sci U S A ; 118(3)2021 01 19.

Article em En | MEDLINE | ID: mdl-33431678

Assuntos

Colite/imunologia; NF-kappa B/imunologia; Processamento de Proteína Pós-Traducional; Infecções por Salmonella/imunologia; Choque Séptico/imunologia; Proteínas Supressoras da Sinalização de Citocina/imunologia; Proteínas Adaptadoras de Transdução de Sinal/genética; Proteínas Adaptadoras de Transdução de Sinal/imunologia; Animais; Colite/induzido quimicamente; Colite/genética; Colite/mortalidade; Sulfato de Dextrana; Genes Reporter; Interleucina-1beta/genética; Interleucina-1beta/imunologia; Interleucina-6/genética; Interleucina-6/imunologia; Lipopolissacarídeos; Luciferases/genética; Luciferases/imunologia; MAP Quinase Quinase Quinases/genética; MAP Quinase Quinase Quinases/imunologia; Camundongos; Camundongos Knockout; NF-kappa B/genética; Ligação Proteica; Infecções por Salmonella/genética; Infecções por Salmonella/microbiologia; Infecções por Salmonella/mortalidade; Salmonella typhimurium/imunologia; Salmonella typhimurium/patogenicidade; Choque Séptico/induzido quimicamente; Choque Séptico/genética; Choque Séptico/mortalidade; Transdução de Sinais; Proteínas Supressoras da Sinalização de Citocina/genética; Análise de Sobrevida; Ubiquitinação

Palavras-chave

ASB1; NF-κB; TAB2; inflammatory response; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Salmonella / Choque Séptico / Processamento de Proteína Pós-Traducional / NF-kappa B / Colite / Proteínas Supressoras da Sinalização de Citocina Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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