BMI1 enables extensive expansion of functional erythroblasts from human peripheral blood mononuclear cells.

Liu, Senquan; Wu, Mengyao; Lancelot, Moira; Deng, Jiusheng; Gao, Yongxing; Roback, John D; Chen, Tong; Cheng, Linzhao

Liu, Senquan; Wu, Mengyao; Lancelot, Moira; Deng, Jiusheng; Gao, Yongxing; Roback, John D; Chen, Tong; Cheng, Linzhao.

Afiliação

Liu S; Blood and Cell Therapy Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Wu M; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Hematology, Huashan Hospital of Fudan University, Shanghai 200040, China.
Lancelot M; Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Deng J; Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Gao Y; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Roback JD; Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address: jroback@emory.edu.
Chen T; Division of Hematology, Huashan Hospital of Fudan University, Shanghai 200040, China. Electronic address: chentong@fudan.edu.cn.
Cheng L; Blood and Cell Therapy Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China; Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: lcheng2@jh.edu.

Mol Ther ; 29(5): 1918-1932, 2021 05 05.

Article em En | MEDLINE | ID: mdl-33484967

Assuntos

Eritroblastos/citologia; Transfusão de Eritrócitos/métodos; Eritrócitos/citologia; Leucócitos Mononucleares/citologia; Complexo Repressor Polycomb 1/genética; Adulto; Animais; Técnicas de Cultura de Células; Diferenciação Celular; Proliferação de Células; Células Cultivadas; Sangue Fetal; Humanos; Camundongos; Modelos Animais

Palavras-chave

BMI1; RBC; enucleation; erythroblasts; gene editing; sickle cell disease; transfusion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucócitos Mononucleares / Eritroblastos / Transfusão de Eritrócitos / Eritrócitos / Complexo Repressor Polycomb 1 Limite: Adult / Animals / Humans Idioma: En Revista: Mol Ther Assunto da revista: BIOLOGIA MOLECULAR / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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