Clonal Expansion of Tumor-Infiltrating T Cells and Analysis of the Tumor Microenvironment within Esophageal Squamous Cell Carcinoma Relapsed after Definitive Chemoradiation Therapy.

Mori, Takahiro; Kumagai, Kenichi; Nasu, Keisuke; Yoshizawa, Takamasa; Kuwano, Koji; Hamada, Yoshiki; Kanazawa, Hideki; Suzuki, Ryuji

Mori, Takahiro; Kumagai, Kenichi; Nasu, Keisuke; Yoshizawa, Takamasa; Kuwano, Koji; Hamada, Yoshiki; Kanazawa, Hideki; Suzuki, Ryuji.

Afiliação

Mori T; Departments of Clinical Oncology and Gastroenterological Surgery, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0392, Japan.
Kumagai K; Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0385, Japan.
Nasu K; Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aobaku, Sendai 980-8574, Japan.
Yoshizawa T; Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0385, Japan.
Kuwano K; Department of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Hamada Y; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.
Kanazawa H; Department of Rheumatology and Clinical Immunology, Clinical Research Center for Rheumatology and Allergy, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara 252-0385, Japan.
Suzuki R; Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan.

Int J Mol Sci ; 22(3)2021 01 22.

Article em En | MEDLINE | ID: mdl-33499345

Assuntos

Quimiorradioterapia/métodos; Carcinoma de Células Escamosas do Esôfago/terapia; Linfócitos do Interstício Tumoral/imunologia; Neoplasias Bucais/terapia; Linfócitos T/imunologia; Microambiente Tumoral; Antígeno B7-H1/metabolismo; Biomarcadores Tumorais; Biópsia; Endoscopia; Carcinoma de Células Escamosas do Esôfago/imunologia; Esofagectomia; Humanos; Neoplasias Bucais/imunologia; Recidiva Local de Neoplasia; Prognóstico; Doses de Radiação; Receptores de Antígenos de Linfócitos T/metabolismo; Terapia de Salvação

Palavras-chave

CD8; PD-L1; TCR repertoire; definitive chemoradiation therapy; esophageal squamous cell carcinoma; prognostic marker; salvage esophagectomy; tumor-infiltrating T cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Linfócitos T / Linfócitos do Interstício Tumoral / Microambiente Tumoral / Quimiorradioterapia / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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