Support of BCP-ALL-cells by autologous bone marrow Th-cells involves induction of AID expression but not widespread AID off-target mutagenesis.

Traxel, Sabrina; Lehmann, Julia; Richard, Stefanie; Sidorov, Semjon; Niggli, Felix; Berger, Christoph; Nadal, David; Bürgler, Simone

Traxel, Sabrina; Lehmann, Julia; Richard, Stefanie; Sidorov, Semjon; Niggli, Felix; Berger, Christoph; Nadal, David; Bürgler, Simone.

Afiliação

Traxel S; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. sabrina.traxel@uzh.ch.
Lehmann J; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Richard S; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Sidorov S; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Niggli F; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Berger C; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Nadal D; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Bürgler S; Experimental Infectious Diseases and Cancer Research, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland. simone.buergler@uzh.ch.

Cancer Immunol Immunother ; 70(8): 2275-2289, 2021 Aug.

Article em En | MEDLINE | ID: mdl-33507341

Assuntos

Medula Óssea/imunologia; Citidina Desaminase/imunologia; Linfoma de Células B/imunologia; Mutagênese/imunologia; Leucemia-Linfoma Linfoblástico de Células Precursoras B/imunologia; Linfócitos T Auxiliares-Indutores/imunologia; Adolescente; Adulto; Linfócitos B/imunologia; Linhagem Celular Tumoral; Células Cultivadas; Criança; Pré-Escolar; Feminino; Humanos; Lactente; Masculino; Mutação/imunologia; Transdução de Sinais/imunologia; Adulto Jovem

Palavras-chave

Activation-induced cytidine deaminase; B-cell precursor acute lymphoblastic leukemia; Mutational signature; T-helper cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medula Óssea / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Linfoma de Células B / Mutagênese / Linfócitos T Auxiliares-Indutores / Citidina Desaminase Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suíça

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