Selective electrochemical detection of antidepressant drug imipramine in blood serum and urine samples using an antimony telluride-graphite nanofiber electrode.
Mikrochim Acta
; 188(2): 60, 2021 01 28.
Article
em En
| MEDLINE
| ID: mdl-33511456
ABSTRACT
A high-performance imipramine (IMPR) sensor has been developed based on metal chalcogenide-carbon composite materials. The antimony telluride-graphite nanofiber (Sb2Te3-GNF, hereafter SBT-GNF) composite was synthesized by the hydrothermal method and confirmed by X-ray powder diffraction (XRD) pattern. The morphology, crystalline lattice, and chemical states were characterized by HRTEM, SAED, and XPS analysis. The characterizations confirmed the formation of an effective composite, SBT-GNF. The SBT-GNF was fabricated as a disposable sensor electrode with a screen-printed carbon electrode (SPCE) and examined for the detection of IMPR by differential pulse voltammetry (DPV). The electroanalytical results of SBT-GNF are compared with the SBT and GNF, and the rational design of effective composite is discussed. SBT-GNF/SPCE showed a good linear range (0.0151.8 µM), sensitivity (1.35 ± 0.1 µA µM-1 cm-2), and low LOD (4 ± 2 nM). Moreover, the SBT-GNF/SPCE revealed high selectivity and high tolerance limit against potential interfering compounds in blood serum and urine samples. Therefore, this electrochemical sensor can be applicable for the detection of tricyclic antidepressant drug IMPR in clinical and pharmaceutical analysis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nanofibras
/
Imipramina
/
Antidepressivos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Mikrochim Acta
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Taiwan