Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.

Szabó, András; Toldi, Vanda; Gazda, Lívia Diána; Demcsák, Alexandra; Tozsér, József; Sahin-Tóth, Miklós

Szabó, András; Toldi, Vanda; Gazda, Lívia Diána; Demcsák, Alexandra; Tozsér, József; Sahin-Tóth, Miklós.

Afiliação

Szabó A; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA. Electronic address: an
Toldi V; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Doctoral School of Molecular, Cell and Immune Biology, University of Debrecen, Debrecen, Hungary.
Gazda LD; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Doctoral School of Molecular, Cell and Immune Biology, University of Debrecen, Debrecen, Hungary.
Demcsák A; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA.
Tozsér J; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Sahin-Tóth M; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA; Department of Surgery, University of California Los Angeles, Los Angeles, California, USA. Electronic address: msahintoth@mednet.ucla.ed

J Biol Chem ; 296: 100343, 2021.

Article em En | MEDLINE | ID: mdl-33515547

Assuntos

Pancreatite Crônica/genética; Inibidor da Tripsina Pancreática de Kazal/genética; Tripsina/metabolismo; Células HEK293; Humanos; Modelos Moleculares; Mutação de Sentido Incorreto; Pancreatite Crônica/metabolismo; Ligação Proteica; Inibidor da Tripsina Pancreática de Kazal/metabolismo

Palavras-chave

equilibrium binding assay; pancreatitis; reactive-site peptide bond; trypsin inhibitor; tyrosine sulfation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tripsina / Inibidor da Tripsina Pancreática de Kazal / Pancreatite Crônica Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article

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