Factor VIIa induces extracellular vesicles from the endothelium: a potential mechanism for its hemostatic effect.

Das, Kaushik; Keshava, Shiva; Ansari, Shabbir A; Kondreddy, Vijay; Esmon, Charles T; Griffin, John H; Pendurthi, Usha R; Rao, L Vijaya Mohan

Das, Kaushik; Keshava, Shiva; Ansari, Shabbir A; Kondreddy, Vijay; Esmon, Charles T; Griffin, John H; Pendurthi, Usha R; Rao, L Vijaya Mohan.

Afiliação

Das K; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Keshava S; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Ansari SA; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Kondreddy V; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Esmon CT; Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK; and.
Griffin JH; Department of Molecular Medicine, Scripps Research Institute, La Jolla, CA.
Pendurthi UR; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.
Rao LVM; Department of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX.

Blood ; 137(24): 3428-3442, 2021 06 17.

Article em En | MEDLINE | ID: mdl-33534910

Assuntos

Endotélio Vascular/metabolismo; Vesículas Extracelulares/metabolismo; Fator VIIa/farmacologia; Hemostasia/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Receptor PAR-1/metabolismo; Substituição de Aminoácidos; Animais; Vesículas Extracelulares/genética; Hemostasia/genética; Humanos; Camundongos; Camundongos Knockout; Mutação de Sentido Incorreto; Receptor PAR-1/genética; Proteínas Recombinantes/farmacologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Fator VIIa / Receptor PAR-1 / Células Endoteliais da Veia Umbilical Humana / Vesículas Extracelulares / Hemostasia Limite: Animals / Humans Idioma: En Revista: Blood Ano de publicação: 2021 Tipo de documento: Article

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