Determinants of lung disease progression measured by lung clearance index in children with cystic fibrosis.
Eur Respir J
; 58(1)2021 07.
Article
em En
| MEDLINE
| ID: mdl-33542049
ABSTRACT
The lung clearance index (LCI) measured by the multiple breath washout (MBW) test is sensitive to early lung disease in children with cystic fibrosis. While LCI worsens during the preschool years in cystic fibrosis, there is limited evidence to clarify whether this continues during the early school age years, and whether the trajectory of disease progression as measured by LCI is modifiable.A cohort of children (healthy and cystic fibrosis) previously studied for 12â
months as preschoolers were followed during school age (5-10â
years). LCI was measured every 3â
months for a period of 24â
months using the Exhalyzer D MBW nitrogen washout device. Linear mixed effects regression was used to model changes in LCI over time.A total of 582 MBW measurements in 48 healthy subjects and 845 measurements in 64 cystic fibrosis subjects were available. The majority of children with cystic fibrosis had elevated LCI at the first preschool and first school age visits (57.8% (37 out of 64)), whereas all but six had normal forced expiratory volume in 1â
s (FEV1) values at the first school age visit. During school age years, the course of disease was stable (-0.02â
units·year-1 (95% CI -0.14-0.10). LCI measured during preschool years, as well as the rate of LCI change during this time period, were important determinants of LCI and FEV1, at school age.Preschool LCI was a major determinant of school age LCI; these findings further support that the preschool years are critical for early intervention strategies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose Cística
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Eur Respir J
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Canadá