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Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney.
Takahashi, Naohiro; Kikuchi, Hiroaki; Usui, Ayaka; Furusho, Taisuke; Fujimaru, Takuya; Fujiki, Tamami; Yanagi, Tomoki; Matsuura, Yoshiaki; Asano, Kenichi; Yamamoto, Kouhei; Ando, Fumiaki; Susa, Koichiro; Mandai, Shintaro; Mori, Takayasu; Rai, Tatemitsu; Uchida, Shinichi; Arita, Makoto; Sohara, Eisei.
Afiliação
  • Takahashi N; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Kikuchi H; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Usui A; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Furusho T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Fujimaru T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Fujiki T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Yanagi T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Matsuura Y; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Asano K; Laboratory of Immune Regulation, The School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
  • Yamamoto K; Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
  • Ando F; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Susa K; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Mandai S; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Mori T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Rai T; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Uchida S; Department of Nephrology, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
  • Arita M; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa, 230-0045, Japan. makoto.arita@riken.jp.
  • Sohara E; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan. makoto.arita@riken.jp.
Clin Exp Nephrol ; 25(5): 445-455, 2021 May.
Article em En | MEDLINE | ID: mdl-33595729
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Araquidonato 12-Lipoxigenase / Araquidonato 15-Lipoxigenase / Prostaglandina D2 / Insuficiência Renal Crônica / Metabolismo dos Lipídeos / Rim Limite: Animals / Humans / Male Idioma: En Revista: Clin Exp Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Araquidonato 12-Lipoxigenase / Araquidonato 15-Lipoxigenase / Prostaglandina D2 / Insuficiência Renal Crônica / Metabolismo dos Lipídeos / Rim Limite: Animals / Humans / Male Idioma: En Revista: Clin Exp Nephrol Assunto da revista: NEFROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão