FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study.
Oral Dis
; 28(3): 771-776, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-33600013
ABSTRACT
OBJECTIVE:
To examine the association of four FCN1 SNPs -542G>A (rs10120023), -144C>A (rs10117466), +6658C>T (rs148649884), and +7895A>G (rs150625869) with dental caries in Polish children. SUBJECTS ANDMETHODS:
The study group consisted of 261 15-year-old Polish teenagers 82 children with "higher" caries experience (having Decayed Missing Filled Teeth, DMFT >5) and 179 children with "lower" caries experience (having DMFT ≤5). Moreover, in additional comparison, a group of 229 children with caries experience (DMFT ≥1) was compared to a caries-free (DMFT =0) group of 32 children. Extraction of genomic DNA was performed from buccal swabs, and genotyping was performed by Real-Time PCR.RESULTS:
FCN1 SNPs +6658C>T and +7895A>G appeared to be monomorphic in our sample. The genotype, allele, or haplotype distributions in FCN1 SNPs -542G>A and -144C>A in children with "higher" caries experience did not differ significantly from those in "lower" caries experience group. Similar results with no significant differences were demonstrated for subjects with DMFT ≥1 compared to subjects with DMFT =0.CONCLUSION:
FCN1 SNPs are not the markers of dental caries susceptibility in Polish children.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cárie Dentária
/
Suscetibilidade à Cárie Dentária
/
Lectinas
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Oral Dis
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Polônia