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COVID-19, HHV6 and MOG antibody: A perfect storm.
Jumah, Muruj; Rahman, Farah; Figgie, Mark; Prasad, Ankita; Zampino, Anthony; Fadhil, Ali; Palmer, Kaitlin; Buerki, Robin Arthur; Gunzler, Steven; Gundelly, Praveen; Abboud, Hesham.
Afiliação
  • Jumah M; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Rahman F; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Figgie M; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Prasad A; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Zampino A; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Fadhil A; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Palmer K; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Buerki RA; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Gunzler S; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Gundelly P; Case Western Reserve University School of Medicine, Cleveland, OH, USA; Infectious disease department, University Hospitals of Cleveland, Cleveland, OH, USA.
  • Abboud H; Neurology Department, University Hospitals of Cleveland, Cleveland, OH, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA; Multiple Sclerosis and Neuroimmunology Program, University Hospitals of Cleveland, Cleveland, OH, USA. Electronic address: hesham.abboud@uhhospitals.or
J Neuroimmunol ; 353: 577521, 2021 04 15.
Article em En | MEDLINE | ID: mdl-33607505
ABSTRACT

BACKGROUND:

Serious neurological complications of SARS-CoV-2 are increasingly being recognized. CASE We report a novel case of HHV6 myelitis with parainfectious MOG-IgG in the setting of COVID-19-induced lymphopenia and hypogammaglobulinemia. The patient experienced complete neurological recovery with gancyclovir, high dose corticosteroids, and plasma exchange. To our knowledge, this is the first case of HHV6 reactivation in the central nervous system in the setting of COVID19 infection and the first case of MOG-IgG myelitis in the setting of SARS-CoV-2 and HHV6 coinfection.

CONCLUSION:

Patients with neurological manifestations in the setting of COVID19-related immunodeficiency should be tested for opportunistic infections including HHV6. Viral infection is a known trigger for MOG-IgG and therefore this antibody should be checked in patients with SARS-CoV-2 associated demyelination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Roseolovirus / Coinfecção / COVID-19 / Linfopenia / Mielite Transversa Limite: Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Roseolovirus / Coinfecção / COVID-19 / Linfopenia / Mielite Transversa Limite: Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos