Association of apolipoprotein levels with peripheral arterial disease: a meta-analysis of literature studies.
Eur J Prev Cardiol
; 28(18): 1980-1990, 2022 02 09.
Article
em En
| MEDLINE
| ID: mdl-33624016
ABSTRACT
AIMS:
Lower limb peripheral artery disease (PAD) is a leading cause of atherosclerotic cardiovascular disease (ASCVD). Discordant data are available on the association between apolipoprotein and PAD. We performed a meta-analyses on the association between apolipoprotein (apo)B, apoA-I, and apoB/apoA-I ratio with PAD. METHODS ANDRESULTS:
PubMed, Web of Science, Scopus databases were systematically searched. Studies providing data about apoB, apoA-I, apoB/apoA-I ratio in PAD subjects and non-PAD controls were included. Differences between PAD and non-PAD subjects were expressed as mean difference (MD) with pertinent 95% confidence intervals (95%CI). Twenty-two studies were included. Peripheral artery disease subjects showed higher apoB (MD 12.5 mg/dL, 95%CI 2.14, 22.87) and lower apoA-I levels (MD -7.11 mg/dL, 95%CI -11.94, -2.28) than non-PAD controls. Accordingly, ApoB/ApoA-I ratio resulted higher in PAD subjects than non-PAD controls (MD 0.11, 95% CI 0.00, 0.21). Non-HDL-C showed a direct association with the difference in apoB (z-value 4.72, P < 0.001) and an inverse association with the difference of apoA-I (z-value -2.43, P = 0.015) between PAD subjects and non-PAD controls. An increasing BMI was associated with an increasing difference in apoA-I values between PAD subjects and non-PAD controls (z-value 1.98, P = 0.047).CONCLUSIONS:
Our meta-analysis suggests that PAD subjects exhibit increased apoB and reduced apoA-I levels, accompanied by an increased apoB/apoA-I ratio as compared with non-PAD controls.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aterosclerose
/
Doença Arterial Periférica
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Eur J Prev Cardiol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Itália