PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.

Shen, Yuqian; Zhang, Zi Chao; Cheng, Shanshan; Liu, An; Zuo, Jian; Xia, Shuting; Liu, Xian; Liu, Wenhua; Jia, Zhengping; Xie, Wei; Han, Junhai

Shen, Yuqian; Zhang, Zi Chao; Cheng, Shanshan; Liu, An; Zuo, Jian; Xia, Shuting; Liu, Xian; Liu, Wenhua; Jia, Zhengping; Xie, Wei; Han, Junhai.

Afiliação

Shen Y; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Zhang ZC; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address: zhangzc@seu.edu.cn.
Cheng S; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Liu A; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Zuo J; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Xia S; Institute of Neuroscience, Soochow University, Suzhou 215000, China.
Liu X; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Liu W; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Jia Z; Neurosciences and Mental Health Program, Hospital for Sick Children, University of Toronto, Toronto, ON M5S 1A1, Canada.
Xie W; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China.
Han J; School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China; Department of Neurology, Affiliated ZhongDa Hospital, Institute

Mol Cell ; 81(7): 1425-1438.e10, 2021 04 01.

Article em En | MEDLINE | ID: mdl-33662272

Assuntos

Proteínas de Ligação a DNA/metabolismo; Hipocampo/metabolismo; Depressão Sináptica de Longo Prazo; Elongação Traducional da Cadeia Peptídica; Fator 2 de Elongação de Peptídeos/metabolismo; Receptores de Glutamato Metabotrópico/biossíntese; Animais; Proteínas de Ligação a DNA/genética; Células HEK293; Células HeLa; Humanos; Camundongos; Camundongos Knockout; Fator 2 de Elongação de Peptídeos/genética; Fosforilação; Receptores de Glutamato Metabotrópico/genética

Palavras-chave

PQBP1; Renpenning syndrome; eEF2; mGluR-LTD; novel object recognition; phosphorylation; protein synthesis; spatial recognition; translational elongation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Elongação Traducional da Cadeia Peptídica / Receptores de Glutamato Metabotrópico / Fator 2 de Elongação de Peptídeos / Depressão Sináptica de Longo Prazo / Proteínas de Ligação a DNA / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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