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Hypoxia Active Platinum(IV) Prodrugs of Orotic Acid Selective to Liver Cancer Cells.
Maji, Moumita; Bhattacharya, Indira; Acharya, Sourav; Chakraborty, Manas Pratim; Gupta, Arnab; Mukherjee, Arindam.
Afiliação
  • Maji M; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
  • Bhattacharya I; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
  • Acharya S; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
  • Chakraborty MP; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
  • Gupta A; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
  • Mukherjee A; Department of Chemical Sciences and Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Inorg Chem ; 60(7): 4342-4346, 2021 Apr 05.
Article em En | MEDLINE | ID: mdl-33711231
ABSTRACT
Platinum(IV) complexes of orotic acid selectively target liver cancer cells displaying enhanced activity and higher uptake in Hep G2. The comparatively higher expression of Organic Anion Transporter 2 (OAT2) in Hep G2 and decrease in toxicity in the presence of OAT2 inhibitor suggest its involvement in the uptake of the complexes. They are resistant to sequestration by the copper transporter ATP7B, unlike cisplatin and oxaliplatin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organoplatínicos / Ácido Orótico / Pró-Fármacos / Hipóxia Celular / Neoplasias Hepáticas / Antineoplásicos Limite: Humans Idioma: En Revista: Inorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organoplatínicos / Ácido Orótico / Pró-Fármacos / Hipóxia Celular / Neoplasias Hepáticas / Antineoplásicos Limite: Humans Idioma: En Revista: Inorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia