Ocular radioimmunoscintigraphy: sensitivity and practical considerations.
J Nucl Med
; 29(6): 1031-7, 1988 Jun.
Article
em En
| MEDLINE
| ID: mdl-3373313
ABSTRACT
Ocular radioimmunoscintigraphy was performed in 20 patients using 99mTc-labeled monoclonal antibody 225.28S, F(ab')2 fragments. Radioimmunoscintigraphy was positive in 13 patients and the diagnosis of ocular melanoma was confirmed by enucleation of the eye or clinical follow-up. Scintigraphy was positive in one patient with lymph node metastasis from an ocular melanoma. In six patients immunoscintigraphy was negative. Using this technique a sensitivity of 92.8% was achieved for detecting ocular melanomas. Single photon emission tomography helped to separate the lesions situated in the nasal quadrant of the eye from the adjacent nasopharyngeal activity. With appropriate imaging techniques small tumors of the order of 3 x 5 x 3 mm could be detected clearly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecnécio
/
Neoplasias Oculares
/
Melanoma
/
Anticorpos Monoclonais
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Reino Unido