Estimation of drug exposure by machine learning based on simulations from published pharmacokinetic models: The example of tacrolimus.

Woillard, Jean-Baptiste; Labriffe, Marc; Prémaud, Aurélie; Marquet, Pierre

Woillard, Jean-Baptiste; Labriffe, Marc; Prémaud, Aurélie; Marquet, Pierre.

Afiliação

Woillard JB; Univ. Limoges, IPPRITT, F-87000 Limoges, France; INSERM, IPPRITT, U1248, F-87000 Limoges, France; Department of Pharmacology and Toxicology, CHU Limoges, F-87000 Limoges, France. Electronic address: jean-baptiste.woillard@unilim.fr.
Labriffe M; Univ. Limoges, IPPRITT, F-87000 Limoges, France; INSERM, IPPRITT, U1248, F-87000 Limoges, France; Department of Pharmacology and Toxicology, CHU Limoges, F-87000 Limoges, France.
Prémaud A; Univ. Limoges, IPPRITT, F-87000 Limoges, France; INSERM, IPPRITT, U1248, F-87000 Limoges, France.
Marquet P; Univ. Limoges, IPPRITT, F-87000 Limoges, France; INSERM, IPPRITT, U1248, F-87000 Limoges, France; Department of Pharmacology and Toxicology, CHU Limoges, F-87000 Limoges, France.

Pharmacol Res ; 167: 105578, 2021 05.

Article em En | MEDLINE | ID: mdl-33775863

Assuntos

Imunossupressores/sangue; Aprendizado de Máquina; Tacrolimo/sangue; Adulto; Área Sob a Curva; Humanos; Modelos Biológicos; Método de Monte Carlo

Palavras-chave

Machine learning; Monte Carlo simulations; Population pharmacokinetics; Tacrolimus; Therapeutic drug monitoring; Xgboost

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tacrolimo / Aprendizado de Máquina / Imunossupressores Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Adult / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2021 Tipo de documento: Article

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