The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1.

Yu, Wenjuan; Singh, Ramesh; Wang, Zhao; O'Malley, Bert W; Yi, Ping

Yu, Wenjuan; Singh, Ramesh; Wang, Zhao; O'Malley, Bert W; Yi, Ping.

Afiliação

Yu W; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
Singh R; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Wang Z; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
O'Malley BW; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
Yi P; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. Electronic address: pyi@bcm.edu.

J Biol Chem ; 296: 100739, 2021.

Article em En | MEDLINE | ID: mdl-33991522

Assuntos

Proteínas Substratos do Receptor de Insulina/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Transdução de Sinais; Fator 4 Associado a Receptor de TNF/metabolismo; Células HEK293; Humanos; Células MCF-7; Ubiquitinação

Palavras-chave

Akt; TNF receptor associated factor (TRAF); insulin receptor substrate 1 (IRS-1); insulin-like growth factor (IGF); proliferation; protein phosphorylation; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Transdução de Sinais / Fator 4 Associado a Receptor de TNF / Proteínas Substratos do Receptor de Insulina Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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