Non-viral nanoparticles for RNA interference: Principles of design and practical guidelines.

Liu, Zehua; Wang, Shiqi; Tapeinos, Christos; Torrieri, Giulia; Känkänen, Voitto; El-Sayed, Nesma; Python, Andre; Hirvonen, Jouni T; Santos, Hélder A

Liu, Zehua; Wang, Shiqi; Tapeinos, Christos; Torrieri, Giulia; Känkänen, Voitto; El-Sayed, Nesma; Python, Andre; Hirvonen, Jouni T; Santos, Hélder A.

Afiliação

Liu Z; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Wang S; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Tapeinos C; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Torrieri G; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Känkänen V; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
El-Sayed N; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Python A; Center of Data Science, Zhejiang University, Hangzhou 310058, China.
Hirvonen JT; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland.
Santos HA; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki FI-00014, Finland. Electronic address: helder.santos@helsinki.fi.

Adv Drug Deliv Rev ; 174: 576-612, 2021 07.

Article em En | MEDLINE | ID: mdl-34019958

Assuntos

Nanopartículas; Interferência de RNA; RNA Interferente Pequeno/administração & dosagem; Animais; Técnicas de Transferência de Genes; Humanos; Oligonucleotídeos/administração & dosagem

Palavras-chave

Clinical translation; Endosome escape; Leukocytes targeting; Non-viral nanoparticles; RNA encapsulation; RNA interference

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Interferente Pequeno / Interferência de RNA / Nanopartículas Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Revista: Adv Drug Deliv Rev Assunto da revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Finlândia

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