Association of Midlife Depressive Symptoms with Regional Amyloid-ß and Tau in the Framingham Heart Study.
J Alzheimers Dis
; 82(1): 249-260, 2021.
Article
em En
| MEDLINE
| ID: mdl-34024836
ABSTRACT
BACKGROUND:
Depressive symptoms predict increased risk for dementia decades before the emergence of cognitive symptoms. Studies in older adults provide preliminary evidence for an association between depressive symptoms and amyloid-ß (Aß) and tau accumulation. It is unknown if similar alterations are observed in midlife when preventive strategies may be most effective.OBJECTIVE:
The study aim was to evaluate the association between depressive symptoms and cerebral Aß and tau in a predominately middle-aged cohort with examination of the apolipoprotein (APOE) É4 allele as a moderator.METHODS:
Participants included 201 adults (mean age 53±8 years) who underwent 11C-Pittsburgh Compound B amyloid and 18F-Flortaucipir tau positron emission tomography (PET) imaging. Depressive symptoms were evaluated with the Center for Epidemiological Studies Depression Scale (CES-D) at the time of PET imaging, as well as eight years prior. Associations between depressive symptoms at both timepoints, as well as depression (CES-D≥16), with regional Aß and tau PET retention were evaluated with linear regression adjusting for age and sex. Interactions with the APOE É4 allele were explored.RESULTS:
Depressive symptoms and depression were not associated with PET outcomes in the overall sample. However, among APOE É4 allele carriers, there was a significant cross-sectional association between depressive symptoms and increased tau PET uptake in the entorhinal cortex (ß=â0.446, SEâ=â0.155, pâ=â0.006) and amygdala (ß=â0.350, SEâ=â0.133, pâ=â0.012).CONCLUSION:
Although longitudinal studies are necessary, the results suggest that APOE É4 carriers with depressive symptoms may present with higher susceptibility to early tau accumulation in regions integral to affective regulation and memory consolidation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos beta-Amiloides
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Proteínas tau
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Córtex Entorrinal
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Depressão
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Tonsila do Cerebelo
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos