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PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).
Hawley, Eric; Gehlhausen, Jeffrey; Karchugina, Sofiia; Chow, Hoi-Yee; Araiza-Olivera, Daniela; Radu, Maria; Smith, Abbi; Burks, Ciersten; Jiang, Li; Li, Xiaohong; Bessler, Waylan; Masters, Andrea; Edwards, Donna; Burgin, Callie; Jones, David; Yates, Charles; Clapp, D Wade; Chernoff, Jonathan; Park, Su-Jung.
Afiliação
  • Hawley E; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Gehlhausen J; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Karchugina S; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Chow HY; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Araiza-Olivera D; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Radu M; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
  • Smith A; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Burks C; Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Jiang L; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Li X; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Bessler W; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Masters A; Clinical Pharmacology Analytical Core, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Edwards D; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Burgin C; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Jones D; Clinical Pharmacology Analytical Core, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Yates C; Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Clapp DW; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Chernoff J; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  • Park SJ; Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Hum Mol Genet ; 30(17): 1607-1617, 2021 08 12.
Article em En | MEDLINE | ID: mdl-34075397
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurofibromatose 2 / Quinases Ativadas por p21 Limite: Animals Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurofibromatose 2 / Quinases Ativadas por p21 Limite: Animals Idioma: En Revista: Hum Mol Genet Assunto da revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos