Translation stress and collided ribosomes are co-activators of cGAS.

Wan, Li; Juszkiewicz, Szymon; Blears, Daniel; Bajpe, Prashanth Kumar; Han, Zhong; Faull, Peter; Mitter, Richard; Stewart, Aengus; Snijders, Ambrosius P; Hegde, Ramanujan S; Svejstrup, Jesper Q

Wan, Li; Juszkiewicz, Szymon; Blears, Daniel; Bajpe, Prashanth Kumar; Han, Zhong; Faull, Peter; Mitter, Richard; Stewart, Aengus; Snijders, Ambrosius P; Hegde, Ramanujan S; Svejstrup, Jesper Q.

Afiliação

Wan L; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Juszkiewicz S; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Blears D; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark.
Bajpe PK; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Han Z; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark.
Faull P; Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Mitter R; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Stewart A; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Snijders AP; Protein Analysis and Proteomics Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Hegde RS; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, Panum Institute, Blegdamsvej 3B, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: jsvejstrup@sund.ku.dk.

Mol Cell ; 81(13): 2808-2822.e10, 2021 07 01.

Article em En | MEDLINE | ID: mdl-34111399

Assuntos

Núcleo Celular; Nucleotidiltransferases; Biossíntese de Proteínas; Ribossomos; Transdução de Sinais; Estresse Fisiológico; Transporte Ativo do Núcleo Celular; Núcleo Celular/química; Núcleo Celular/genética; Núcleo Celular/metabolismo; Células HEK293; Humanos; Nucleotidiltransferases/química; Nucleotidiltransferases/genética; Nucleotidiltransferases/metabolismo; Ribossomos/química; Ribossomos/genética; Ribossomos/metabolismo

Palavras-chave

ASCC3; IRF3; STING; ZNF598; cGAS; innate immunity; interferon signalling; mRNA translation; ribosome collision; ribosome-associated protein quality control

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribossomos / Estresse Fisiológico / Biossíntese de Proteínas / Transdução de Sinais / Núcleo Celular / Nucleotidiltransferases Limite: Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido

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