Branched-chain amino acid metabolism is regulated by ERR&#945; in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.

Sjögren, Rasmus J O; Rizo-Roca, David; Chibalin, Alexander V; Chorell, Elin; Furrer, Regula; Katayama, Shintaro; Harada, Jun; Karlsson, Håkan K R; Handschin, Christoph; Moritz, Thomas; Krook, Anna; Näslund, Erik; Zierath, Juleen R

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes.

Sjögren, Rasmus J O; Rizo-Roca, David; Chibalin, Alexander V; Chorell, Elin; Furrer, Regula; Katayama, Shintaro; Harada, Jun; Karlsson, Håkan K R; Handschin, Christoph; Moritz, Thomas; Krook, Anna; Näslund, Erik; Zierath, Juleen R.

Afiliação

Sjögren RJO; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Rizo-Roca D; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Chibalin AV; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Chorell E; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Furrer R; Biozentrum, University of Basel, Basel, Switzerland.
Katayama S; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
Harada J; Cardiovascular-Metabolics Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan.
Karlsson HKR; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Handschin C; Biozentrum, University of Basel, Basel, Switzerland.
Moritz T; Swedish Metabolomics Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, Umeå, Sweden.
Krook A; Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.
Näslund E; Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Zierath JR; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden. juleen.zierath@ki.se.

Diabetologia ; 64(9): 2077-2091, 2021 09.

Article em En | MEDLINE | ID: mdl-34131782

Assuntos

Diabetes Mellitus Tipo 2; Aminoácidos de Cadeia Ramificada/metabolismo; Animais; Cromatografia Líquida; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Glucose/metabolismo; Humanos; Camundongos; Fibras Musculares Esqueléticas/metabolismo; Músculo Esquelético/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Receptores de Estrogênio; Espectrometria de Massas em Tandem; Receptor ERRalfa Relacionado ao Estrogênio

Palavras-chave

Branched-chain amino acid; Oestrogen-related receptor α; Oral glucose tolerance test; Peroxisome proliferator-activated receptor Î³ coactivator 1-α; Skeletal muscle; Type 2 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Diabetologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Suécia

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