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Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling.
Trauelsen, Mette; Hiron, Thomas K; Lin, Da; Petersen, Jacob E; Breton, Billy; Husted, Anna Sofie; Hjorth, Siv A; Inoue, Asuka; Frimurer, Thomas M; Bouvier, Michel; O'Callaghan, Chris A; Schwartz, Thue W.
Afiliação
  • Trauelsen M; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark.
  • Hiron TK; Wellcome Trust Centre for Human Genetics and NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
  • Lin D; Wellcome Trust Centre for Human Genetics and NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
  • Petersen JE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark.
  • Breton B; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
  • Husted AS; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark.
  • Hjorth SA; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark.
  • Inoue A; Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
  • Frimurer TM; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark.
  • Bouvier M; Department of Biochemistry and Molecular Medicine, Institute for Research in Immunology and Cancer, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
  • O'Callaghan CA; Wellcome Trust Centre for Human Genetics and NIHR Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7BN, UK.
  • Schwartz TW; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Maersk Tower, 2200 Copenhagen, Denmark. Electronic address: tws@sund.ku.dk.
Cell Rep ; 35(11): 109246, 2021 06 15.
Article em En | MEDLINE | ID: mdl-34133934
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Succínico / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Receptores Acoplados a Proteínas G / Espaço Extracelular / Macrófagos Limite: Female / Humans / Male Idioma: En Revista: Cell Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Ácido Succínico / Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP / Receptores Acoplados a Proteínas G / Espaço Extracelular / Macrófagos Limite: Female / Humans / Male Idioma: En Revista: Cell Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Dinamarca